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Virulence. 2010 Jan-Feb;1(1):42-4. doi: 10.4161/viru.1.1.10229.

One step at a time: action mechanism of Sushi 1 antimicrobial peptide and derived molecules.

Author information

1
Singapore-MIT Alliance, Singapore.

Abstract

Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and bio-functional assays we were able to determine the different steps occurring during the action of the α-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structure-function relationship of AMPs.

PMID:
21178412
PMCID:
PMC3080192
DOI:
10.4161/viru.1.1.10229
[Indexed for MEDLINE]
Free PMC Article

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