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Dis Markers. 2010;29(3-4):199-206. doi: 10.3233/DMA-2010-0733.

Epidermodysplasia verruciformis and susceptibility to HPV.

Author information

1
Center for Clinical Studies, University of Texas Health Science Center, Houston, TX, USA.

Abstract

Epidermodysplasia verruciformis has been addressed in depth in the recent literature despite its rarity. The disease is characterized by a persistence in human papillomavirus infections and development of cutaneous malignancies, usually happening more frequently and at a younger age than in the general population. Because of the role of immunodeficiency to viral antigens eventually leading to cancer, EV has become a model for understanding a viral role in cutaneous oncogenesis. Susceptibility loci for EV have been mapped and encoded protein functions are becoming better understood. Discoveries of novel mutations and further study of EV-associated HPV serotypes in lesional and nonlesional skin of affected patients and the general population may help generate a cohesive theory regarding the true role of a defective immune barrier in oncogenesis.

PMID:
21178278
PMCID:
PMC3835378
DOI:
10.3233/DMA-2010-0733
[Indexed for MEDLINE]
Free PMC Article

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