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Phytomedicine. 2011 Jun 15;18(8-9):625-9. doi: 10.1016/j.phymed.2010.11.006. Epub 2010 Dec 21.

A pilot study of the multiherb Kampo medicine bakumondoto for cough in patients with chronic obstructive pulmonary disease.

Author information

1
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Abstract

OBJECTIVES:

To evaluate the effect of bakumondoto, Kampo medicine, on cough in patients with chronic obstructive pulmonary disease (COPD).

DESIGN:

A 16-week, randomized, open-labeled, cross-over design.

SETTING:

Outpatient clinics at one university hospital and two general hospitals in Japan from May 2007 to March 2009.

PARTICIPANTS:

Twenty-four elderly patients (14 men and 9 women aged over 65) with COPD.

INTERVENTION:

Treatment with or without bakumondoto for 8 weeks in a cross-over design.

MEASUREMENTS:

The primary outcome measurements were the frequency and intensity of cough assessed by a visual analogue scale (VAS) and a daily cough diary. Secondary outcome measurements were quality of life (QOL) assessed using St. George's Respiratory Questionnaire (SGRQ) and lung functions measured using spirometry.

RESULTS:

Treatment with bakumondoto significantly improved cough severity during the first treatment period (week 0 vs. week 8, p=0.004) and showed a trend to decrease during the second treatment period (week 8 vs. week 16, p=0.129) assessed by the VAS. Neither QOL nor lung function was affected by the treatment with bakumondoto.

CONCLUSION:

Bakumondoto may be effective in suppressing cough in elderly patients with COPD. To further confirm the efficacy, a larger and placebo-controlled study with objective cough assessment is necessary.

PMID:
21177084
DOI:
10.1016/j.phymed.2010.11.006
[Indexed for MEDLINE]

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