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FEBS Lett. 2011 Jan 21;585(2):390-6. doi: 10.1016/j.febslet.2010.12.020. Epub 2010 Dec 19.

Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes.

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Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepcion, Concepcion, Chile.


In addition to its role as a strong antioxidant, vitamin C regulates the differentiation of several cell lineages. In vertebrate skeletal muscle, the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. To gain insights into the possible involvement of intracellular vitamin C on early myogenesis, we investigated the regulation of SVCT2 expression in cultures of chick fetal myoblasts. SVCT2 expression increases in cultures of both, slow and fast muscle-derived myoblasts, as they fuse to form mainly fast myotubes. Interestingly, we found that SVCT2 could be positively modulated by potassium-induced depolarization of myotubes. These findings suggest that SVCT2-mediated uptake of vitamin C could play diverse roles on skeletal muscle development and physiology.

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