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Clin Exp Rheumatol. 2010 Nov-Dec;28(6 Suppl 63):S71-7. Epub 2010 Dec 22.

Arterial stiffness and proinflammatory cytokines in fibromyalgia syndrome.

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Department of Internal Medicine, Arthritis and Autoimmunity Research Centre, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.



We assessed arterial stiffness and inflammatory cytokine profiles in fibromyalgia syndrome (FMS) patients and analysed the association between them.


Twenty-seven FMS patients and 29 age-matched premenopausal healthy controls were enrolled in this study. Arterial stiffness was assessed by pulse wave velocity (PWV) and augmentation index (AIx) from pulse waveform analysis. Levels of serum interleukin-1β (IL-1β), IL-6, IL-8, and vascular endothelial growth factor (VEGF) were measured by enzyme-linked immunosorbent assay, and a colorimetric assay was used for measurement of serum nitric oxide (NO) metabolites (nitrate and nitrite, NOx) level. Statistical analyses included the Mann-Whitney U-test and Spearman's correlation coefficient analysis.


Higher AIx and AIx@HR75 (aortic AIx at a heart rate of 75 beats/min) were noted in FMS compared to those in the controls after adjustment using covariants (p(adj)=0.023 and p(adj)<0.001). However, there were no differences between the three regional PWVs of the two groups at the aorta-femoral, femoral-dorsalis, and aorta-radialis arteries (p(adj)>0.05 for all). FMS subjects had significantly higher serum IL-8 levels than did the healthy controls (327.9±588.7 vs. 76.4±90.5, p(adj)=0.041). However, there were no significant differences in serum IL-1β, IL-6, VEGF, or NOx levels between the FMS patients and the controls (p(adj)>0.05 of all). Serum IL-8 level did not correlate with PWV and AIx in FMS patients.


This study demonstrates higher AIx and IL-8 levels in FMS subjects compared to those of the controls. However, arterial stiffness including AIx in FMS was not determined by the serum IL-8 level.

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