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Chem Commun (Camb). 2011 Mar 7;47(9):2586-8. doi: 10.1039/c0cc03075a. Epub 2010 Dec 21.

Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines.

Author information

1
Department of Medicinal Chemistry, University of Vienna, Vienna, Austria.

Abstract

A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of diastereoisomers. Docking studies into a homology model of human P-gp provide first insights into potential binding areas for these compounds.

PMID:
21173990
DOI:
10.1039/c0cc03075a
[Indexed for MEDLINE]

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