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Nat Rev Genet. 2011 Feb;12(2):81-5. doi: 10.1038/nrg2915. Epub 2010 Dec 21.

Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing.

Author information

1
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA. wulff@sas.upenn.edu

Abstract

Catalysed by members of the adenosine deaminase acting on RNA (ADAR) family of enzymes, adenosine-to-inosine (A-to-I) editing converts adenosines in RNA molecules to inosines, which are functionally equivalent to guanosines. Recently, global approaches to studying this widely conserved phenomenon have emerged. The use of bioinformatics, high-throughput sequencing and other approaches has increased the number of known editing sites by several orders of magnitude, and we now have a greater understanding of the control and the biological significance of editing. This Progress article reviews some of these recent global studies and their results.

PMID:
21173775
PMCID:
PMC3075016
DOI:
10.1038/nrg2915
[Indexed for MEDLINE]
Free PMC Article

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