Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):35-9. doi: 10.1073/pnas.1009492108. Epub 2010 Dec 20.

Quantifying the biophysical characteristics of Plasmodium-falciparum-parasitized red blood cells in microcirculation.

Author information

1
Division of Applied Mathematics, Brown University, Providence, RI 02912, USA.

Abstract

The pathogenicity of Plasmodium falciparum (Pf) malaria results from the stiffening of red blood cells (RBCs) and its ability to adhere to endothelial cells (cytoadherence). The dynamics of Pf-parasitized RBCs is studied by three-dimensional mesoscopic simulations of flow in cylindrical capillaries in order to predict the flow resistance enhancement at different parasitemia levels. In addition, the adhesive dynamics of Pf-RBCs is explored for various parameters revealing several types of cell dynamics such as firm adhesion, very slow slipping along the wall, and intermittent flipping. The parasite inside the RBC is modeled explicitly in order to capture phenomena such as "hindered tumbling" motion of the RBC and the sudden transition from firm RBC cytoadherence to flipping on the endothelial surface. These predictions are in quantitative agreement with recent experimental observations, and thus the three-dimensional modeling method presented here provides new capabilities for guiding and interpreting future in vitro and in vivo studies of malaria.

PMID:
21173269
PMCID:
PMC3017137
DOI:
10.1073/pnas.1009492108
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center