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J Exp Med. 2010 Dec 20;207(13):2781-4. doi: 10.1084/jem.20102428.

Induced pluripotent stem cell-derived human platelets: one step closer to the clinic.

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1
Differentiation and Cancer Program, Center for Genomic Regulation, 08003 Barcelona, Spain.

Erratum in

  • J Exp Med. 2011 Jan 17;208(1):213.

Abstract

The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.

PMID:
21173109
PMCID:
PMC3005227
DOI:
10.1084/jem.20102428
[Indexed for MEDLINE]
Free PMC Article
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