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Lipids Health Dis. 2010 Dec 20;9:144. doi: 10.1186/1476-511X-9-144.

Treatment of dyslipidemia in patients with type 2 diabetes.

Author information

1
Cardiovascular Division, Scottsdale Healthcare Research Institute, Scottsdale, AZ, USA. kvijaymd@gmail.com

Abstract

Type 2 diabetes is associated with significant cardiovascular morbidity and mortality. Although low-density lipoprotein cholesterol levels may be normal in patients with type 2 diabetes, insulin resistance drives a number of changes in lipid metabolism and lipoprotein composition that render low-density lipoprotein cholesterol and other lipoproteins more pathogenic than species found in patients without type 2 diabetes. Dyslipidemia, which affects almost 50% of patients with type 2 diabetes, is a cardiovascular risk factor characterized by elevated triglyceride levels, low high-density lipoprotein cholesterol levels, and a preponderance of small, dense, low-density lipoprotein particles. Early, aggressive pharmacological management is advocated to reduce low-density lipoprotein cholesterol levels, regardless of baseline levels. A number of lipid-lowering agents, including statins, fibrates, niacin, and bile acid sequestrants, are available to target normalization of the entire lipid profile. Despite use of combination and high-dose lipid-lowering agents, many patients with type 2 diabetes do not achieve lipid targets. This review outlines the characteristics and prevalence of dyslipidemia in patients with type 2 diabetes and discusses strategies that may reduce the risk of cardiovascular disease in this population.

PMID:
21172030
PMCID:
PMC3022752
DOI:
10.1186/1476-511X-9-144
[Indexed for MEDLINE]
Free PMC Article
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