Format

Send to

Choose Destination
Expert Rev Mol Diagn. 2011 Jan;11(1):65-78. doi: 10.1586/erm.10.104.

Blood-based diagnostics of traumatic brain injuries.

Author information

1
Banyan Biomarkers, Inc., 12085 Research Drive, Alachua, FL 32615, USA.

Abstract

Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of clinical severity are the subject of debate and are being supplemented with structural and functional neuroimaging, as the need for biomarkers that reflect elements of the pathogenetic process is widely recognized. Basic science research and developments in the field of proteomics have greatly advanced our knowledge of the mechanisms involved in damage and have led to the discovery and rapid detection of new biomarkers that were not available previously. However, translating this research for patients' benefits remains a challenge. In this article, we summarize new developments, current knowledge and controversies, focusing on the potential role of these biomarkers as diagnostic, prognostic and monitoring tools of brain-injured patients.

PMID:
21171922
PMCID:
PMC3063529
DOI:
10.1586/erm.10.104
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center