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Otolaryngol Pol. 2010 Jun;64(7):17-21. doi: 10.1016/S0030-6657(10)70003-2.

[The effects of cochleostomy of hearing threshold in animal experiment].

[Article in Polish]

Author information

1
Katedra i Klinika Otolaryngologii WUM. olimpiaset@op.pl

Abstract

INTRODUCTION:

To assess an effect of cochleostomy on hearing threshold in guinea pigs.

MATERIAL AND METHODS:

The authors performed animal experiments using five 3-month-old guinea pigs. Before experiment hearing threshold were evaluated. Surgery involved access to the temporal bone by a post-auricular incision. After a wide opening of the bulla cochleostomy was created (10,000 turn/min, diamond bur of 0.8 mm diameter). Hearing threshold was identified on the basis of presence of wave V in auditory brainstem responses (ABR) for click and frequency-specific stimulation. Also morphology and latency changes for wave V for this stimulation was assessed. Hearing status was evaluated before, just after and 1-, 2-, and 4-weeks after surgery. For surgical procedure and ABR examination all animals were anesthetized with an intramuscular injection of ketamine (50 mg/kg) mixed with xylazine (9 mg/kg) in the supplemental doses. After surgery the animal was treated by antibioticoterapy for 3 days--Enrofloksacyna 0.3 ml subcutaneouly and analgesic--Tolfedine 0.05 mg in second day.

RESULTS:

Four week observation of ABR morphology and hearing thresholds for click and frequency-specific stimulation of 100 dB SPL intensity showed only temporary changes confirming that cochleostomy did not affect cochlear function.

CONCLUSIONS:

The correctly performed cochleostomy in guinea pigs did not affect persistently the cochlear function indicating that such an option of CI electrode insertion in patients is safe.

PMID:
21171305
DOI:
10.1016/S0030-6657(10)70003-2
[Indexed for MEDLINE]

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