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Int J Nanomedicine. 2010 Nov 26;5:1057-65. doi: 10.2147/IJN.S14912.

Recent advances in PEG-PLA block copolymer nanoparticles.

Author information

1
Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Abstract

Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability. Additionally, due to their smaller particle size and modified surface, these nanoparticles can accumulate in inflammation or target locations to enhance drug efficacy and reduce toxicity. Recent advances in PEG-PLA block copolymer nanoparticles, including the synthesis of PEG-PLA and the preparation of PEG-PLA nanoparticles, were introduced in this study, in particular the drug release and modifiable characteristics of PEG-PLA nanoparticles and their application in pharmaceutical preparations.

KEYWORDS:

PEG-PLA; block copolymer; drug delivery system; nanoparticles

PMID:
21170353
PMCID:
PMC3000205
DOI:
10.2147/IJN.S14912
[Indexed for MEDLINE]
Free PMC Article

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