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J Mol Endocrinol. 2011 Feb 15;46(2):R43-63. doi: 10.1677/JME-10-0068. Print 2011 Apr.

Ghrelin and lipid metabolism: key partners in energy balance.

Author information

1
Department of Physiology, School of Medicine, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela (A Coruña) 15782, Spain.

Abstract

Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates central and peripheral lipid metabolism through specific control of hypothalamic AMP-activated protein kinase (AMPK), a critical metabolic gauge regulating both cellular and whole-body energy homeostasis. In this review, we summarize the new milestones of ghrelin's actions on energy balance, with particular focus on its molecular interaction with hypothalamic AMPK and fatty acid metabolism. Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome.

PMID:
21169422
DOI:
10.1677/JME-10-0068
[Indexed for MEDLINE]

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