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Exp Mol Pathol. 2011 Apr;90(2):173-8. doi: 10.1016/j.yexmp.2010.12.002. Epub 2010 Dec 17.

MicroRNAs in chronic lymphocytic leukemia.

Author information

1
Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Recent research, conducted primarily in basic science laboratories, has indicated a role for microRNAs (miRNAs) in the pathogenesis and prognosis of this disease. MiRNAs are small, non-coding, functional RNAs, that mediate post-transcriptional inhibition of messenger RNAs. Because miRNA expression levels in CLL patients differ from that of normal patients, there may be a role for these novel small molecules as biomarkers in this disease.

PMID:
21168405
DOI:
10.1016/j.yexmp.2010.12.002
[Indexed for MEDLINE]

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