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Protoplasma. 2011 Oct;248(4):641-50. doi: 10.1007/s00709-010-0250-5. Epub 2010 Dec 17.

The apicoplast.

Author information

1
School of Botany, University of Melbourne, Melbourne, VIC, 3010, Australia. gim@unimelb.edu.au

Abstract

Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin. In this review, the discovery of the apicoplast and its integration, function and purpose are explored. New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development are reviewed.

PMID:
21165662
DOI:
10.1007/s00709-010-0250-5
[Indexed for MEDLINE]

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