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Nature. 2010 Dec 16;468(7326):911-20. doi: 10.1038/nature09645.

Emerging properties of animal gene regulatory networks.

Author information

1
Division of Biology 156-29, California Institute of Technology, Pasadena, California 91125, USA. Davidson@caltech.edu

Abstract

Gene regulatory networks (GRNs) provide system level explanations of developmental and physiological functions in the terms of the genomic regulatory code. Depending on their developmental functions, GRNs differ in their degree of hierarchy, and also in the types of modular sub-circuit of which they are composed, although there is a commonly employed sub-circuit repertoire. Mathematical modelling of some types of GRN sub-circuit has deepened biological understanding of the functions they mediate. The structural organization of various kinds of GRN reflects their roles in the life process, and causally illuminates both developmental and evolutionary process.

PMID:
21164479
PMCID:
PMC3967874
DOI:
10.1038/nature09645
[Indexed for MEDLINE]
Free PMC Article

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