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Fitoterapia. 2011 Jun;82(4):528-33. doi: 10.1016/j.fitote.2010.12.003. Epub 2010 Dec 13.

Phytoconstituents from Vitex agnus-castus fruits.

Author information

1
UIC/NIH Center for Botanical Dietary Supplements Research, PCRPS, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.

Abstract

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.

PMID:
21163339
PMCID:
PMC3081944
DOI:
10.1016/j.fitote.2010.12.003
[Indexed for MEDLINE]
Free PMC Article

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