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J Nat Prod. 2011 Jan 28;74(1):21-5. doi: 10.1021/np1005345. Epub 2010 Dec 16.

Stachylines A-D from the sponge-derived fungus Stachylidium sp.

Author information

1
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.

Abstract

The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.

PMID:
21162532
PMCID:
PMC3070797
DOI:
10.1021/np1005345
[Indexed for MEDLINE]
Free PMC Article

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