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World J Gastrointest Oncol. 2010 Feb 15;2(2):117-20. doi: 10.4251/wjgo.v2.i2.117.

Three novel NEIL1 promoter polymorphisms in gastric cancer patients.

Author information

1
Masanori Goto, Kazuya Shinmura, Hong Tao, Haruhiko Sugimura, First Department of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3192, Japan.

Abstract

AIM:

To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.

METHODS:

The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.

RESULTS:

Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.

CONCLUSION:

Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

KEYWORDS:

Base excision repair; Gastric cancer; Genetic polymorphism; NEIL1

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