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Nat Rev Cancer. 2011 Jan;11(1):59-67. doi: 10.1038/nrc2966. Epub 2010 Dec 16.

RNA interference in the clinic: challenges and future directions.

Author information

1
U.T. M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Abstract

Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.

PMID:
21160526
PMCID:
PMC3199132
DOI:
10.1038/nrc2966
[Indexed for MEDLINE]
Free PMC Article

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