Format

Send to

Choose Destination
J Rheumatol. 2011 Mar;38(3):446-9. doi: 10.3899/jrheum.100427. Epub 2010 Dec 15.

The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

Author information

1
Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

Erratum in

  • J Rheumatol. 2011 May;38(5):968.

Abstract

OBJECTIVE:

To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.

METHODS:

The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.

RESULTS:

We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.

CONCLUSION:

Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

PMID:
21159834
DOI:
10.3899/jrheum.100427
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center