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Cancer Cell. 2010 Dec 14;18(6):539-41. doi: 10.1016/j.ccr.2010.11.032.

Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma.

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Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.


In this issue of Cancer Cell, Rui et al. identify JAK2 and JMJDC2 as two contiguous, coamplified oncogenes in primary mediastinal B cell and Hodgkin lymphoma. Together, JAK2 and JMJD2C induce major changes in chromatin structure and gene expression. Targeting these proteins with small molecules represents a new avenue for therapy.

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