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FEBS Lett. 2011 Jan 21;585(2):335-40. doi: 10.1016/j.febslet.2010.12.007. Epub 2010 Dec 13.

Cyanobacterial phytochrome Cph2 is a negative regulator in phototaxis toward UV-A.

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Division of Life Science, Korea Basic Science Institute, Daejeon, Republic of Korea.


We investigated the wavelength dependence and photon-fluence rate response relationship for phototaxis of wild-type and a cyanobacterial phytochrome 2 (cph2) mutant in cyanobacterium Synechocystis sp. PCC 6803. Compared to wild-type, the cph2 mutant exhibited maximal activity for positive phototaxis at the near-UV spectral range. Two cysteine to serine substitutions in two chromophore-binding domains showed a similar cph2 mutant phenotype under UV-A. Epistasis of a pixJ mutation over a cph2 mutation implied that pixJ gene acts downstream of the cph2 gene with respect to UV-A-induced positive phototaxis. Therefore, we suggest that Cph2 is essential for the inhibition of positive phototaxis toward UV-A.

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