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Yonsei Med J. 2011 Jan;52(1):45-50. doi: 10.3349/ymj.2011.52.1.45.

Clinical experiences of pheochromocytoma in Korea.

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1
Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

PURPOSE:

We report herein 119 patients with pheochromocytoma at our institute over the last 23 years.

MATERIALS AND METHODS:

Between 1986 and 2009, 119 patients were diagnosed with pheochromocytoma at our institute. We reviewed the medical records of these patients.

RESULTS:

Of 119 patients, 45 were male and 74 were female, and mean age was 43.83 ± 13.49 years. Forty-three patients (36.1%) were diagnosed incidentally, and 8 patients (6.7%) were found to have familial pheochromocytoma. The mean dimension of the tumors was 5.89 ± 3.18 cm. 4 patients had bilateral tumors; three of these patients were found to have familial pheochromocytoma and 1 patient was diagnosed with malignant pheochromocytoma. A total of eight patients (6.7%) were found to have malignant pheochromocytoma. In 1 patient, metastasis to a lymph node was found at the time of diagnosis. Metastases were found at a mean of 49 ± 25.83 (6-75) months after surgery in the other seven patients. 6 patients died of malignant pheochromocytoma at a mean of 31 ± 28.71 months (1-81) after diagnosis, and the other 2 patients survived for 15 and 24 months, respectively.

CONCLUSION:

Approximately 35% of patients with pheochromocytoma are diagnosed incidentally, and the number of detected cases is increasing. Although familial pheochromocytoma was found only in 6.7% of the patients, genetic testing should be considered in all patients, especially in patients with a family history, young age, or multifocal, bilateral, extra-adrenal, or malignant tumors. Given that malignant pheochromocytomas are frequently diagnosed during the follow-up period, long-term follow-up is necessary to confirm the absence of recurrence or metastasis.

PMID:
21155034
PMCID:
PMC3017707
DOI:
10.3349/ymj.2011.52.1.45
[Indexed for MEDLINE]
Free PMC Article
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