Format

Send to

Choose Destination
J Biomed Biotechnol. 2011;2011:969618. doi: 10.1155/2011/969618. Epub 2010 Dec 1.

Surgical approaches to create murine models of human wound healing.

Author information

1
Department of Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University, 257 Campus Drive, GK210, Stanford, CA 94305, USA.

Abstract

Wound repair is a complex biologic process which becomes abnormal in numerous disease states. Although in vitro models have been important in identifying critical repair pathways in specific cell populations, in vivo models are necessary to obtain a more comprehensive and pertinent understanding of human wound healing. The laboratory mouse has long been the most common animal research tool and numerous transgenic strains and models have been developed to help researchers study the molecular pathways involved in wound repair and regeneration. This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.

PMID:
21151647
PMCID:
PMC2995912
DOI:
10.1155/2011/969618
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center