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Nat Rev Cancer. 2011 Jan;11(1):68-75. doi: 10.1038/nrc2950. Epub 2010 Dec 2.

What is the malignant nature of human ductal carcinoma in situ?

Author information

1
George Mason University, Center for Applied Proteomics and Molecular Medicine, Manassas, Virginia 20110, USA.

Abstract

Invasive, genetically abnormal carcinoma progenitor cells have been propagated from human and mouse breast ductal carcinoma in situ (DCIS) lesions, providing new insights into breast cancer progression. The survival of DCIS cells in the hypoxic, nutrient-deprived intraductal niche could promote genetic instability and the derepression of the invasive phenotype. Understanding potential survival mechanisms, such as autophagy, that might be functioning in DCIS lesions provides strategies for arresting invasion at the pre-malignant stage. A new, open trial of neoadjuvant therapy for patients with DCIS constitutes a model for testing investigational agents that target malignant progenitor cells in the intraductal niche.

PMID:
21150936
PMCID:
PMC3756606
DOI:
10.1038/nrc2950
[Indexed for MEDLINE]
Free PMC Article

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