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AIDS. 2011 Jan 28;25(3):388-90. doi: 10.1097/QAD.0b013e3283427e05.

Paradoxically elevated efavirenz concentrations in HIV/tuberculosis-coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy.

Author information

1
The Miriam Hospital, Providence, Rhode Island 02906, USA. akwara@lifespan.org

Abstract

Some individuals have higher efavirenz plasma concentrations during rifampin-containing tuberculosis (TB) therapy, contrary to the expected induction effect of rifampin. Among HIV-infected patients without (n = 38) and with TB on rifampin-containing therapy (n = 18), we tested the hypothesis that drug-gene interaction may explain the highly variable drug interactions. Two-way analysis of variance revealed a significant interaction between CYP2B6 516G→T polymorphism and rifampin-containing therapy, suggesting that efavirenz dose adjustment may need to be individualized on the basis of the patient's genotype.

PMID:
21150552
PMCID:
PMC6170200
DOI:
10.1097/QAD.0b013e3283427e05
[Indexed for MEDLINE]
Free PMC Article

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