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Nephron Clin Pract. 2011;118(2):c122-9. doi: 10.1159/000321140. Epub 2010 Dec 10.

Impact of polymorphisms of the genes encoding angiotensin II-forming enzymes on the progression of IgA nephropathy.

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1
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Abstract

BACKGROUND/AIMS:

Angiotensin II has been shown to play an important role in various renal diseases. Genetic polymorphisms of the renin-angiotensin system have been reported to be related to the clinical outcomes in immunoglobulin A nephropathy (IgAN). We investigated the association of polymorphisms of the genes encoding major angiotensin II-forming enzymes with the development and progression of IgAN among Korean patients.

METHODS:

A total of 261 IgAN patients and 300 healthy controls were studied. The polymorphisms of angiotensin-converting enzyme gene (I/D, A2350G) and chymase (CMA) gene (rs1800875, rs1800876) were determined.

RESULTS:

No significant difference was observed in the genotype and allele frequencies of the polymorphisms between IgAN patients and controls. The frequency of AA/AG genotypes of CMA rs1800875 and CC/CT genotype of CMA rs1800876 were significantly higher in patients with progressive disease course than in those with stable course (53.2 vs. 38.6%, p = 0.029; 89.6 vs. 78.3%, p = 0.031, respectively). In the Cox regression model with adjustment for clinical risk factors, CMA rs1800875 AA/AG genotypes remained an independent risk factor (hazard ratio 2.351; p = 0.001).

CONCLUSION:

Our results suggest that the CMA rs1800875 polymorphism is associated with the progression of IgAN in Korean patients.

PMID:
21150220
DOI:
10.1159/000321140
[Indexed for MEDLINE]
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