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Biosci Biotechnol Biochem. 2010;74(12):2367-73. Epub 2010 Dec 7.

Multiple functions of the S-phase checkpoint mediator.

Author information

1
Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan. katsunori@kwansei.ac.jp

Abstract

There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.

PMID:
21150122
DOI:
10.1271/bbb.100583
[Indexed for MEDLINE]
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