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Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22665-70. doi: 10.1073/pnas.1017069108. Epub 2010 Dec 13.

Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness.

Author information

1
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. shinung@neurostat.mit.edu

Abstract

Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.

PMID:
21149695
PMCID:
PMC3012501
DOI:
10.1073/pnas.1017069108
[Indexed for MEDLINE]
Free PMC Article

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