Send to

Choose Destination
Neuron. 1990 Jul;5(1):81-9.

Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster.

Author information

Centro de Biologia Molecular, Universidad Autonoma/CSIC, Canto Blanco, Madrid, Spain.


Loss of function mutations in genes of the achaete-scute complex (ASC) or in the gene vnd of D. melanogaster result in neural hypoplasia. Two types of defects contribute to the development of the neural hypoplasic phenotype: a lower than normal proportion of neuroblasts delaminate from the neuroectoderm, and there is abundant cell death in the neural primordium during later stages. In addition, we found that increasing the copy number of ASC wild-type alleles leads to effects opposite to those caused by their deletion. All of these results indicate that the function of these genes is required for the commitment of neuroectodermal cells as neuroblasts and that the loss of these genetic functions causes the cells either to take on an epidermal fate or to die.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center