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Stroke. 2011 Jan;42(1):214-6. doi: 10.1161/STROKEAHA.110.594010. Epub 2010 Dec 9.

Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.

Author information

1
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, the Sahlgrenska Academy, SE-413 45 Gothenburg, Sweden. sandra.olsson@neuro.gu.se

Abstract

BACKGROUND AND PURPOSE:

in a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden.

METHODS:

we examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies.

RESULTS:

no significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13).

CONCLUSIONS:

the single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations.

PMID:
21148441
DOI:
10.1161/STROKEAHA.110.594010
[Indexed for MEDLINE]

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