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Dev Cell. 2010 Dec 14;19(6):797-806. doi: 10.1016/j.devcel.2010.11.011.

Mechanisms of centrosome separation and bipolar spindle assembly.

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1
Department of Medical Oncology, University Medical Center, CG Utrecht, the Netherlands.

Abstract

Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.

PMID:
21145497
DOI:
10.1016/j.devcel.2010.11.011
[Indexed for MEDLINE]
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