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Trends Cell Biol. 2011 Mar;21(3):177-87. doi: 10.1016/j.tcb.2010.11.001. Epub 2010 Dec 7.

Three's company: the fission yeast actin cytoskeleton.

Author information

1
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA. drkovar@uchicago.edu

Abstract

How the actin cytoskeleton assembles into different structures to drive diverse cellular processes is a fundamental cell biological question. In addition to orchestrating the appropriate combination of regulators and actin-binding proteins, different actin-based structures must insulate themselves from one another to maintain specificity within a crowded cytoplasm. Actin specification is particularly challenging in complex eukaryotes where a multitude of protein isoforms and actin structures operate within the same cell. Fission yeast Schizosaccharomyces pombe possesses a single actin isoform that functions in three distinct structures throughout the cell cycle. In this review we explore recent studies in fission yeast that help unravel how different actin structures operate in cells.

PMID:
21145239
PMCID:
PMC3073536
DOI:
10.1016/j.tcb.2010.11.001
[Indexed for MEDLINE]
Free PMC Article
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