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Curr Biol. 2010 Dec 7;20(23):R1022-4. doi: 10.1016/j.cub.2010.11.002.

Male meiosis: Y keep it silenced?

Author information

1
Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fiedlerstr. 42, MTZ, D-01307 Dresden, Germany.

Abstract

What drives defective spermatocytes into apoptosis during mid-pachytene? A recent study identifies the first mid-pachytene 'killer' genes: two Y-linked transcription factors, the Zfy1/2 gene pair, must be silenced to avoid apoptosis.

PMID:
21145018
DOI:
10.1016/j.cub.2010.11.002
[Indexed for MEDLINE]
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