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Curr Opin Struct Biol. 2011 Feb;21(1):12-24. doi: 10.1016/j.sbi.2010.11.002. Epub 2010 Dec 6.

The folding of single domain proteins--have we reached a consensus?

Author information

1
Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA. trsosnic@uchicago.edu

Abstract

Rather than stressing the most recent advances in the field, this review highlights the fundamental topics where disagreement remains and where adequate experimental data are lacking. These topics include properties of the denatured state and the role of residual structure, the nature of the fundamental steps and barriers, the extent of pathway heterogeneity and non-native interactions, recent comparisons between theory and experiment, and finally, dynamical properties of the folding reaction.

PMID:
21144739
PMCID:
PMC3039110
DOI:
10.1016/j.sbi.2010.11.002
[Indexed for MEDLINE]
Free PMC Article

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