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CNS Neurosci Ther. 2011 Dec;17(6):714-22. doi: 10.1111/j.1755-5949.2010.00207.x. Epub 2010 Dec 8.

HPA axis alterations in mental disorders: impact on memory and its relevance for therapeutic interventions.

Author information

1
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf & Schön Klinik Hamburg-Eilbek, Germany.

Abstract

Dysfunctions in hypothalamic-pituitary-adrenal (HPA) axis have been reported for several mental disorders that are also often characterized by memory disturbances. It is now well established that glucocorticoids influence cognitive processes by enhancing memory consolidation and impairing memory retrieval. There is further evidence for an association between HPA axis related disturbances and memory function in mental disorders. The present selective review provides a brief overview of HPA axis dysfunction and its impact on memory function in major depressive disorder, posttraumatic stress disorder, and borderline personality disorder. Furthermore, the relevance of these findings for therapeutic intervention is discussed.

PMID:
21143429
PMCID:
PMC6493879
DOI:
10.1111/j.1755-5949.2010.00207.x
[Indexed for MEDLINE]
Free PMC Article

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