Format

Send to

Choose Destination
Allergy. 2011 May;66(5):658-64. doi: 10.1111/j.1398-9995.2010.02523.x. Epub 2010 Dec 8.

Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study.

Author information

1
National Centre for Register-based Research, Aarhus University, Aarhus, Denmark. pq@ncrr.dk

Abstract

BACKGROUND:

With increasing research suggesting a role of allergy on suicidality, this study, on a population level, delved into how allergy affects risk for suicide completion in the context of mood disorder and other factors.

METHODS:

Based on the entire population of Denmark, we included 27,096 completed suicides and 467,571 live controls matched on sex and age with a nested case-control design. We retrieved personal information on hospital contacts for allergy and other variables from various Danish longitudinal registries and analyzed the data with conditional logistic regression.

RESULTS:

We noted that 1.17% suicide victims, compared with 0.79% matched controls, had a history of hospital contact for allergy and that a history of allergy predicted an increased risk for suicide completion; however, the effect was confined to allergy that led to inpatient treatment (IRR: 1.59, 95% CI: 1.41-1.80). The increased risk was attenuated somewhat but remained significant when adjusted for personal psychiatric history and socioeconomic status. Meanwhile, we observed a nonsignificantly stronger effect in women than in men, and a significant age difference with a stronger effect for individuals at high ages. Moreover, we detected a significant interaction between allergy and mood disorder - even an antagonism effect of the two exposures. Allergy increased suicide risk only in persons with no history of mood disorder, whereas it eliminated suicide risk in those with a history of mood disorder.

CONCLUSIONS:

The findings support a link between allergy and suicidality, with a possible mediating role of mood disorder.

PMID:
21143241
PMCID:
PMC3482428
DOI:
10.1111/j.1398-9995.2010.02523.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center