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J Interferon Cytokine Res. 2011 Jan;31(1):131-5. doi: 10.1089/jir.2010.0127. Epub 2010 Dec 12.

The interferon inducible gene: Viperin.

Author information

1
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. kate.fitzgerald@umassmed.edu

Abstract

The type I interferons (IFNs), IFN-α and -β, are key effector molecules of the immune response to viruses. The anti-viral action of IFNs on virus-infected cells and surrounding tissues is mediated by expression of hundreds of IFN-stimulated genes. Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type I, II, and III IFNs or after infection with a broad range of DNA and RNA viruses. Recent evidence indicates that Viperin disrupts lipid rafts to block influenza virus budding and release and interferes with replication of hepatitis C virus by binding to lipid droplets, small organelles involved in lipid homeostasis that are essential for hepatitis C virus replication. Viperin is also induced by nonviral microbial products such as lipopolysaccharide (LPS) and by a wide range of bacteria, suggesting a broader role in innate antimicrobial defenses.

PMID:
21142818
PMCID:
PMC3021329
DOI:
10.1089/jir.2010.0127
[Indexed for MEDLINE]
Free PMC Article

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