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Neuropsychopharmacology. 1990 Jun;3(3):181-9.

Sodium D-lactate infusion of panic disorder patients.

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Biological Studies Unit, New York State Psychiatric Institute, NY.


Nineteen patients with panic disorder received sodium D,L-lactate (racemic) and pure sodium D-lactate infusions in a pilot study. Sodium D-lactate, which is less metabolically active than L-lactate, produced panic attacks in half the patients. D-Lactate also produced hypocapnia and alkalosis, indicating hyperventilation. These findings suggest that metabolism of lactate is not necessary for the induction of panic in susceptible patients. D-Lactate appears similar to other agents that cause panic in its capacity to stimulate respiration in the preliminary study.

[Indexed for MEDLINE]

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