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Clin Lab Sci. 2010 Fall;23(4):223-7.

C-reactive protein levels are elevated in asthma and asthma-like conditions.

Author information

1
Mayo Clinic, Jacksonville, FL 32224, USA.

Abstract

OBJECTIVE:

Asthma is a chronic disease involving airway hyperresponsiveness. It was proposed that asthma/chronic shortness of breath elicit chronic systemic inflammation even in the absence of episodic events.

DESIGN:

Volunteers completed questionnaires relevant to asthma and/or dyspnea and consented to C-reactive protein (CRP) quantitation. Subject groups were: control (no reported dyspnea) and asthma/shortness of breath [dyspnea] group.

SETTING:

Studies were performed in the Saint Louis metropolitan area.

PARTICIPANTS:

Participants consisted of volunteers aged 18-57. Inclusion criteria were good health, not pregnant, weight > 110 pounds and absence of antiinflammatory medicine use.

RESULTS:

Serum CRP ranged from undetectable to 22,013 ng/mL. Mean results for asthmatic/dyspnea (n = 22) and control (n = 27) groups were 4,203 +/- 1,323 ng/mL and 1,741 +/- 467 ng/mL (p < 0.05) respectively.

CONCLUSION:

Individuals with asthma/asthma-like symptoms have chronic low levels of systemic inflammation despite the absence of episodic pulmonary events. Understanding chronic systemic inflammation relevant to asthma/asthma-like conditions may lead to design of targeted therapeutics.

PMID:
21140796
[Indexed for MEDLINE]

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