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Eur J Med Chem. 2011 Jan;46(1):236-40. doi: 10.1016/j.ejmech.2010.11.009. Epub 2010 Dec 8.

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis.

Author information

1
Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. mjrpq@quimica.uminho.pt

Abstract

The methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by some of us, was reacted in Sonogashira couplings with several (hetero)arylacetylenes. The growth inhibitory activity of the novel methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates obtained was evaluated on three human tumor cell lines (MCF-7, NCI-H460, A375-C5). The para-methoxyphenyl and the ortho- and para-aminophenyl derivatives were the most promising compounds, and their effects were further studied regarding alterations in the normal cell cycle distribution and induction of apoptosis in the NCI-H460 cell line. All three compounds altered cell cycle distribution and the ortho-aminophenyl derivative was further shown to induce apoptosis in the same cell line.

PMID:
21138784
DOI:
10.1016/j.ejmech.2010.11.009
[Indexed for MEDLINE]

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