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Nat Rev Cancer. 2010 Aug;10(8):526-7. doi: 10.1038/nrc2892.

Evolutionary dynamics of cancer prevention.

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1
Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, USA. Robert.Gatenby@Moffitt.org

Abstract

Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.

PMID:
21137109
PMCID:
PMC3744108
[Indexed for MEDLINE]
Free PMC Article
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