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Proteomics Clin Appl. 2008 Jun;2(6):837-44. doi: 10.1002/prca.200780121.

Proteomic insights into cardiac cell death and survival.

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1
Department of Medicine/Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA; Department of Physiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA.

Abstract

Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.

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