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Cell Res. 2011 Jan;21(1):183-95. doi: 10.1038/cr.2010.171. Epub 2010 Dec 7.

Structural studies of NF-κB signaling.

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1
Department of Biochemistry, Weill Cornell Medical College, New York, NY 10021, USA.

Abstract

NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the NF-κB pathway are presented. With the structure information, the following questions may be addressed: (1) How do NF-κBs activate their target genes? (2) How do IκBs inhibit NF-κB activities in the steady state? (3) How do upstream signaling molecules activate the NF-κB pathway? and (4) How do the feedback loops shut down the NF-κB pathway to avoid constitutive NF-κB activation?

PMID:
21135870
PMCID:
PMC3044936
DOI:
10.1038/cr.2010.171
[Indexed for MEDLINE]
Free PMC Article
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