Format

Send to

Choose Destination
Blood Purif. 2011;31(1-3):9-17. doi: 10.1159/000320763. Epub 2010 Dec 7.

Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model.

Author information

1
Emergency Medicine Unit, Department of Cardiology, Franz-Volhard-Klinik, Charité Berlin, Helios Clinic Berlin-Buch, Berlin, Germany.

Abstract

BACKGROUND:

C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction.

METHODS:

We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction.

RESULTS:

We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ~70% in the established treatment system.

CONCLUSION:

We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.

PMID:
21135544
DOI:
10.1159/000320763
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center