Format

Send to

Choose Destination
Bioorg Med Chem. 2011 Jan 1;19(1):486-9. doi: 10.1016/j.bmc.2010.11.004. Epub 2010 Nov 12.

Identification of novel ASK1 inhibitors using virtual screening.

Author information

1
Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan. okamoto@pharmadesign.co.jp

Abstract

Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. We identified novel ASK1 inhibitors by virtual screening from the public chemical library collected by Chemical Biology Research Initiative (CBRI) at the University of Tokyo.

PMID:
21134755
DOI:
10.1016/j.bmc.2010.11.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center