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Exp Cell Res. 2011 Mar 10;317(5):664-73. doi: 10.1016/j.yexcr.2010.11.013. Epub 2010 Dec 4.

Chemokines in cancer related inflammation.

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  • 1Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

Abstract

Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

PMID:
21134366
DOI:
10.1016/j.yexcr.2010.11.013
[PubMed - indexed for MEDLINE]
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