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Acta Pharmacol Sin. 2011 Jan;32(1):12-20. doi: 10.1038/aps.2010.90. Epub 2010 Dec 6.

Hepatocyte growth factor in lung repair and pulmonary fibrosis.

Author information

1
Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, MD 20852, USA.

Abstract

Pulmonary remodeling is characterized by the permanent and progressive loss of the normal alveolar architecture, especially the loss of alveolar epithelial and endothelial cells, persistent proliferation of activated fibroblasts, or myofibroblasts, and alteration of extracellular matrix. Hepatocyte growth factor (HGF) is a pleiotropic factor, which induces cellular motility, survival, proliferation, and morphogenesis, depending upon the cell type. In the adult, HGF has been demonstrated to play a critical role in tissue repair, including in the lung. Administration of HGF protein or ectopic expression of HGF has been demonstrated in animal models of pulmonary fibrosis to induce normal tissue repair and to prevent fibrotic remodeling. HGF-induced inhibition of fibrotic remodeling may occur via multiple direct and indirect mechanisms including the induction of cell survival and proliferation of pulmonary epithelial and endothelial cells, and the reduction of myofibroblast accumulation.

PMID:
21131996
PMCID:
PMC4003323
DOI:
10.1038/aps.2010.90
[Indexed for MEDLINE]
Free PMC Article

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